- Overview
- Data/Specifications
- Literature/Support
- How To Use
- Related Products
Overview
Cartilage-link protein (LP) is a glycoprotein present in cartilage that stabilizes the interaction of aggrecan (versican) with hyaluronic acid (HA) in large proteoglycan aggregates.
Related Terms/Symbols:
- Anti-HAPLN1 antibody
- CRTL1
- Hyaluronan and proteoglycan link protein 1
- LP
- Proteoglycan link protein
- Cartilage-linking protein 1
- HAPLN1 gene
- P10915
Data/Specifications
Immunogen: Link Protein from Bovine nasal cartilage
Clone: 8A4
Host: Mouse
Isotype: IgG
Specificity: This antibody recognizes the structurally related amino acid sequence epitopes … PISRP…and ….PITKP that occur in the two proteoglycan tandem repeat motifs of cartilage LP. Thisantibody can be used to detect intact LP 1,2 & 3 as well as a large number of smaller fragmentsthat are generated through proteolytic cleavage during LP catabolism. It recognizesLP in all animal species from chicken to humans.
Purity: Affinity purified
Form: Clear liquid
Concentration: 0.1 mg/mL
Storage: -20° C
Literature/Support
Antibody to Cartilage Link Protein Insert (PDF, 328 KB)
Joint Disease and Aggrecan (blog post)
How To Use
Applications
Western Blot
IHC
RIA
Technical Notes
No enzyme pretreatment required, however chondroitinase and hyaluronidase will increaseantibody sensitivity by exposing epitopes. For WB chondroitinase and hyaluronidase treatmentis recommended.
Related Products
MD Biosciences成立于1991年，总部位于瑞士，在美国、加拿大和英国设有办事处，是一家领先的研发和临床阶段的制药和生物技术的公司，提供尖端的研究服务，创新的生物产品和先进的诊断能力。我们在炎症和神经学领域拥有超过25年的无与伦比的科学专业知识和专有方法历史，这些使我们一直处于精确医学运动的前沿。
其主要产品包括：
抗体 (软骨蛋白聚糖、胶原蛋白、激素、神经药物)、细胞培养相关试剂 (胶原蛋白、细胞增殖检测、支原体PCR检测)、疾病诱导试剂 (关节炎诱导抗体混合、弗氏佐剂、胶原蛋白II等)、ELISA试剂盒（糖蛋白、细胞因子、激素等）、同型对照、天然蛋白以及重组蛋白（胶原类等）。
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